ADP-ribosylation: Extremely toxic and absolutely essential
Uppladdad av Edin Alidzanovic på juni 04, 2018
Herwig Schüler, Associate Professor, Karolinska Institutet
Protein ADP-ribosylation is a post-translational modification. It is used by pathogenic bacteria to take control over their host cell, but also by enzymes of the PARP family to regulate vital processes including chromatin remodeling, transcription, DNA repair, protein
degradation, and several types of stress response.
I will describe our recent elucidation of the structure and biochemical functions of an ADP-ribosylating toxin from Pseudomonas. I will also summarize our research on the 3D structures of PARP enzymes and how we used these to develop selective PARP inhibitors.